Archive 2010

L-Mesitran shows antibacterial efficacy against antibiotic resistant (incl. ESBL) bacteriae - Maastricht University

Dr. Ellen Stobberingh PhD, an authority on antibiotic resistant bacteriae, from the Maastricht University Hospital, researched the antibacterial activity of L-Mesitran Ointment and Soft.

L-Mesitran Ointment and Soft were compared to controls and other honey products (also Manuka). The testing involved clinical isolates of Staph. aureus, Ps. aeruginosa, Kl. pneumoniae and E. Coli. All bacteriae were antibiotic resistant and Kl. pneumoniae and E. Coli were ESBL producing strains.

L-Mesitran Soft showed to have the highest antibacterial activity against all the antibiotic resistant bacteriae at the lowest dilution, followed by L-Mesitran Ointment.

The full report is available upon request; please send an email to

L-Mesitran muestra eficacia antibacteriana contra bacterias resistentes a antibióticos (incluyendo BLEE)

La Dra. Ellen Stobberingh PhD, una experta en bacterias resistentes a antibióticos, investigó la actividad antibacteriana de L-Mesitran y L-Mesitran Soft desde el Hospital Universitario de Maastricht.

L-Mesitran y L-Mesitran Soft fueron comparados con controles y otros productos a base de miel (incluido Manuka). El estudio involucró cepas aisladas clínicamente de S. aureus, Ps. aeruginosa, Kl. pneumoniae y E. coli. Todas estas bacterias eran resistentes a antibióticos y Kl. pneumoniae y E. coli eran cepas productoras de betalactamasas de espectro extendido (BLEE).

L-Mesitran Soft mostró tener mayor actividad antibacteriana contra todas las bacterias resistentes a los antibióticos en la dilución más baja, seguido por L-Mesitran.

El informe completo está disponible bajo solicitud, por favor envíe un correo electrónico a     

14 December 2010 

L-Mesitran on Twitter!

We are very pleased to announce that we have started a Mesitran Twitter channel with the aim to enhance the discussion on honey and wound healing.

You can follow our tweets simply by joining Twitter:

As a L-Mesitran follower, our tweets will appear on your screen and inform you about the latest on healing wounds with L-Mesitran!

We look forward to welcome you as one of our followers.

November 29, 2010

JWC: L-Mesitran Ointment promotes angiogenic activity

New independent research shows that L-Mesitran Ointment stimulates angiogenesis and that the product is non-cytotoxic. Researchers in the UK investigated the effects of L-Mesitran on angiogenesis using in vitro analogues of angiogenesis and an endothelial proliferation assay.

The authors compared L-Mesitran to: supermarket honey, Manuka honey and artificial honey (sugar solution).Only Manuka honey showed a marked cytotoxic dose response over the range studied. Angiogenesis, which forms granulation tissue, is the process by which a new microcirculation is built to support the healing wound.

L-Mesitran Ointment showed to stimulate angiogenesis, in the same way Manuka did, but significantly better than supermarket honey. Artificial honey had no influence on angiogenesis.

The results were published in the October issue of the Journal of Wound Care, the leading journal for wound care professionals. The article can be found as an abstract via Pubmed or via the Journal of Wound Care website (

Revista “Journal of Wound Care”: L-Mesitran promueve la actividad angiogénica

Una nueva investigación independiente demuestra que L-Mesitran estimula la angiogénesis y que el producto es no citotóxico. Investigadores del Reino Unido han estudiado los efectos de L-Mesitran en la angiogénesis utilizando análogos de la angiogénesis in vitro y ensayos de proliferación endotelial.

Los autores compararon L-Mesitran con: miel de supermercado, miel Manuka y miel artificial (solución de azúcar). Sólo la miel Manuka mostró una dosis - respuesta citotóxica marcada en el rango estudiado. La angiogénesis, que forma el tejido de granulación, es el proceso mediante el cual se forma una nueva microcirculación para apoyar la cicatrización de las heridas.

L-Mesitran demostró que estimula la angiogénesis, de la misma forma que la miel Manuka lo hizo, y significativamente mejor que la miel de supermercado. La miel artificial no tuvo ninguna influencia sobre la angiogénesis.

Los resultados fueron publicados en l’edición d’octubre de la revista “Journal of Wound care”, revista líder para los profesionales al cuidado de las heridas. El artículo se puede encontrar en forma de resumen a través de Pubmed o a través del sitio web de la revista “Journal of Wound care” (

November 15, 2010

Recurrent leg ulcers treated successfully with L-Mesitran

Today's Newsletter concerns our hundredth (!) case study about a very persistent disorder: recurrent leg ulcers.

A 76 year old suffered from an Ulcus Cruris on both legs due to an injury which occurred when he was only twelve years old. Once and a while the wounds tend to open again and previously it took 3 years for the wounds to heal again.

It was remarkable that wound healing stagnated during previous treatments. This time his right leg had been open again for a year and a half; it took less than 7 months with the honey ointment to heal the wounds.

This case also shows that recurrent ulcers have a great influence on the quality of life of the patient. The patient still uses L-Mesitran Soft twice a day to avoid the occurrence of new skin tears.

Click here to read the complete story.

November 1, 2010

Burn - Treated with L-Mesitran

This time we would like to highlight a case study done with L-Mesitran Hydro. A 50-year-old Dutch woman was treated for a burn on her right thigh and abdomen which was caused by hot tea.

The wound was initially unsuccessfully treated with vinegar and hydofiber. The honey-hydrogel however, promoted painless wound healing in the first two days after the start. The wound completely healed in two weeks time without scarring.

You can click here for the complete story.

Please do not hesitate to contact us, should you have questions about the presented study or if you're interested in participating in a similar study.

October 18, 2010

The Foundation for Research and Education of Complementary Treatments about HONEY

The holiday season is (almost) over and it is time for us to resume our L-Mesitran News service. We hope you enjoyed your holiday!

This time we would like to highlight an article about the valuable properties of honey which is published on the biggest unbiased website for complementary and alternative medical science; The Foundation for Research and Education of Complementary Treatments (IOCOB).

In this article the IOCOB concludes that honey seems to work well and often better than conventional dressings and that honey fits really well in the portfolio of wound dressings.

The full article can be found on:

You can click here to read the full article in English.

September 2, 2010

Wounds UK publication: Enterobacter Clocae infection treated with L-Mesitran

The latest Wounds UK journal reports of the treatment of an Enterobacter cloae contaminated wound treated successfully with L-Mesitran Ointment & Net.

A 48 year old obese woman was presented with intermittent clinical stitches on the right tibia after prior surgical removal of a pustulent. After only 5 days of treatment the patient was discharged and treated on an outpatient basis every 2 days which had a positive impact on the patient's psychology since there had been a possibility of “losing” her leg. Treatment was continued and the wound healed completely within two months.

This study was done by Michailidou E, Krokos N, Ziogas P, Margioulas A, Karakatsanis A, Drizis T; surgeons at the General Hospital St. Paul, Thessaloniki,Greece.

The original version of the case study can be downloaded here.

Wounds UK is the most important dedicated wounds communication company in the UK. They are committed to providing affordable education.The Wounds UK Journal is a quarterly peer reviewed journal available online or via subscription.

Please do not hesitate to contact us, should you have questions about the presented publication or if you're interested in participating in a similar study.

July 14, 2010

L-Mesitran website in Spanish!

Estamos orgullosos de anunciar que nuestra página en internet ya está disponible también en español. Toda la información del producto ha sido traducida y una selección de estudios clínicos en español se encuentran online. Otros materiales estarán disponibles bajo petición.

We proudly announce that our website is now also available in Spanish. All product information has been translated and a selection of clinical studies in Spanish is now online. More materials are available upon request. 

June 9, 2010

Bee Part Of It

Bee Part Of It Approximately three-quarters of the crops cultivated worldwide depend to some degree on pollinators to produce your fruits and vegetables. The monetary value of honey bees as commercial pollinators in the USA alone is estimated at about $15-$20 billion annually. But, according to this publication, in the USA the amount of bees has dropped with roughly 30% each year since 2006.

The UK has seen a similar trend, most of their 250 bee species appear to be in decline. The BBC program "Bee Part Of It" started an initiative to help the bees by creating 40,000 new bee-friendly wildflower rich spaces. But it cannot be done without you. How?

That is easy, just plant bee friendly plants or flowers in your own garden and the bees will come. This will help to strengthen the bee colonies and thus help pollinate your fruit and vegetables. Do not forget the bees produce honey, and we do not have to emphasize the importance of honey to you as a subscriber to our newsletter. The BBC website has provided several tips for plants, flowers and other projects you (and your children) can do in the garden.

We hope you will participate in the program and if you are not aware of what are good plants and flowers for the bees and your garden, seek advice from your local garden centre.

Please forward this message to your friends, so they can Bee Part Of It too.

June 2, 2010

2nd degree burn treated with L-Mesitran ointment

It has been a while since we have highlighted one of the most important applications of L-Mesitran Ointment; the treatment of burns.

A 52 year old Dutch female had a large 2nd degree burn on her right hand. The initial silver sulphadiazine treatement proved to be too painful and therefore the switch to L-Mesitran® Ointment was made. The wound healed efficiently in two weeks with little to no scarring.

You can click here to read the complete story.

Please do not hesitate to contact us, should you have questions about the presented study or if you're interested in participating in a similar study.

May 25, 2010

Diabetic Ps.aeruginosa/Streptococci infected wound

In Switzerland a 78 year old obese male, Diabetes Mellitus Type 2, who also suffered from venous insufficiency and edema had a very large wound on his left lower leg. Swabs showed an infection with antibiotic resistant Ps. aeruginosa and Streptococci. The wound was initially treated with antibiotics, collagen and silver dressings, paraffin gauzes, alginates, enzyme products and silicon dressings. Every single one of those treatment methods had little to no success.

Click here to find out how L-Mesitran contributed to infection control and wound healing.

May 10, 2010

L-Mesitran in the treatment of equine pyoderma

The Swedish specialist in veterinary dermatology dr Kerstin Bergvall (dip ECDV) has developed a unique treatment scheme for bacterial pyoderma on the back of the fetlock and lower parts of the equine legs. This disease also goes under the name grease heel or mud fever.

There has been a high incidence of these fetlock problems during the recent cold and dry Swedish winter, affecting the trotters at the major Solvalla race course. Dr. Kerstin Bergvall investigated the problem and found rich bacterial growth of mixed bacteria of the normal flora was found on the affected horses. Damages of the skin’s natural protective barrier due to scratches, humidity, ice and frost damages etc, make it possible for this rich bacterial growth to penetrate the skin and cause an infection.

Her unique treatment scheme below has had a good effect:

1- Mild cases -Apply Alcogel with or without L-Mesitran Soft gel afterwards (no withdrawal time for competition).

2- Moderate cases -Massage with undiluted Vetriderm B-Peroxidase shampoo only on affected areas and apply Alcogel, preferably with L-Mesitran Soft Gel afterwards.

3- Severe/deeper infections -Treat as above -NSAID (withdrawal time before competition!) -if no effect within a week – treat with antibiotics too. Apply Alcogel, and fatty ointment.

Dr Bergvall’s findings were published in the Swedish trotting magazine Travronden , nr 27, 2010. You can find the full English summary here .

May 4, 2010

Ps aeruginosa infected foot

In Finland, an obese male patient (63 years) with Diabetes Type 2 had an infected wound on his right foot. Despite a combination of sharp debridement, maggot therapy, systemic antibiotics and a toe-amputation, the wound did not heal and was still infected with Ps. aeruginosa. A foot amputation was considered, but the patient decided to try the L-Mesitran honey treatment first.

Eight months later a foot-amputation was no longer considered an option and the patient was able to resume his work. The wound was healed without influencing the blood glucose levels or adverse effects.

Click here to read the complete story.

April 26, 2010

Chronic lesion, Pseudomonas/E.agglomerans

A 45 year old female was admitted to the hospital with an extensive lesion on the dorsal surface of the left foot. The patient’s history with this lesion goes back to 2002(!) and since then many times different antibiotic therapies were used, without success. Culture swabs showed Pseudomonas and Enterobacter agglomerans infections.

Within a month this chronically inflamed left foot had a significant improvement with L-Mesitran honey based therapy. The antibacterial activity of L-Mesitran against Pseudomonas aeruginosa and other bacteriae has been proven in multiple cases, but in this case E. agglomerans was susceptible to the honey treatment too.

Click here to read the complete story

April 12, 2010

Pressure Sore

In this edition we would like to highlight the following case study.

A 25 year old male was involved in a car accident and due to the head trauma, which was a result of the accident, he was in a coma for 3 months. During this coma he developed an infected malodorous pressure sore in the coccyx area, despite the use of special anti-pressure sore mattresses and despite the use of systemic antibiotics. After only 10 days of treatment with L-Mesitran ointment the malodour was gone and the wound healed in 5 months without adverse effects.

Click here to read the complete story.

Please do not hesitate to contact us, should you have questions about the presented study or if you're interested in participating in a similar study.

March 31, 2010

New L-Mesitran website!

Welcome to our new website.

The look and feel of the website has been drastically refurbished. The functionality has been updated to make navigation to your favourite pages easier.

Staying informed on the latest news is just a mouse click away via the RSS button at the bottom of each page or via a subscription to our newsletter, which now only requires your email address.

March 24, 2010

Car accident trauma

Recently one of our South African registered users contacted us with the following success-story. On June 1, 2009 her 70 year old mother was knocked down and run over by a car. This accident caused open injuries to her head which were treated with L-Mesitran ointment. Despite the fact that infections are a major concern with trauma after road accidents, and despite the fact that no antibiotics or additional medications were used, no infection was observed. The wounds healed without adverse effects within two to three weeks with little to no scarring.

Click here to read the complete story.

Our special thanks go to Ms Karin Cockburn and her mother; they have made it possible to share this interesting story with you.

Do you have similar experiences with our products and would you like to contribute to the case studies series too? Please do not hesitate to contact us!

March 1, 2010

Diabetic foot Pseudomonas infection, L-Mesitran aided in prevention of amputation

In this edition of our newsletter we would like to highlight the issues involving the treatment of diabetic foot ulcers. A 52 year old male diabetic patient suffering from renal disease had a non-healing wound, Ps Aeruginosa infected, after a ray amputation. After 36 days of treatment with L-Mesitran ointment, the infection was under control and the wound had decreased 50% in size without adverse effects nor any influence on blood glucose levels. More importantly, L-Mesitran ointment was able to prevent a considered amputation of the whole foot!

Click here to read the complete story.

February 1, 2010

Case Study January 2010

In this edition we would like to highlight one of the cases presented to you on the poster we shared in the previous edition of our newsletter. A 38 year old female diabetes patient had a Staph.aureus and E. Coli infected wound on her left calf. Despite the oral antibiotic treatment, the wound remained painful and dirty with slough. The patient was invited to participate in a Malaysian pilot study with L-Mesitran, honey based dressings. After only one week of daily treatment with L-Mesitran ointment, the infection was under control and in 44 days the wound was reduced with 95% without any adverse effects and without influencing the blood glucose levels.

Click here to read the extended version of this story.

January 18, 2010





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